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Principles of Magnetic Resonance Imaging provides a contemporary (2016) introduction to the fundamental concepts of MRI and connects these concepts to the latest MRI developments. Graphic illustrations are used to visualize the complete solution to the Bloch Equation and to clarify underlying biophysical processes, simplified calculations and specific examples are used to add precision in appreciating abstract concepts, and insightful interpretations and clinical examples are presented to appreciate biomedical information in MRI signal. This book contains three parts: I. Section the body into voxels. Part I describes the Fourier encoding matrix for an imaging system, realization of Fourier encoding using the gradient field in magnetic resonance, and k-space sampling. II. What’s in a voxel? Part II examines the effects of the biophysical processes in a voxel on MRI signal. A unified distributional evaluation of the phase factor in a voxel and intuitive biophysical models are developed for MRI signal dependence on Spin fluctuation in a thermal microenvironment, which leads to T1/T2 relaxation rates reflecting cellular contents in a water voxel. Micro- and macro physiological motion, which includes diffusion, perfusion, flow and biomechanical motion. Molecular electron response to the B_0 field, which leads to magnetic susceptibility and chemical shift. The connection of MRI contrast physics to biomedical applications is visualized in the following three terms: 1) cellularity for T2 weighted imaging and diffusion weighted imaging (the latter emphasizing cellular geometry), 2) vascularity for T1 weighted imaging with Gadolinium injection, MR perfusion, and MR angiography, and 3) biomolecularity for MR spectroscopy, and tissue magnetism with emphasis on biometallic imaging. III. How to operate MRI? Part III describes MRI safety issues, hardware, software, MRI scanning, and routine MRI protocols. This MRI book also uses basic concepts to demonstrate and expose students to the latest technological innovations, including: B_(1+)and B_(1-) mapping; Chemical exchange saturation transfer (CEST); Electric property tomography (EPT); Magnetic particle imaging (MPI); MR elastography (MRE); Moving spin tagging including ASL, TRUST, SPAMM and DENSE; Navigator motion compensation; Parallel or accelerated imaging including SENSE, GRAPPA, compressed sensing, simultaneous multiple slices and other Bayesian approaches; Quantitative susceptibility mapping (QSM).
- Sales Rank: #1874065 in Books
- Published on: 2012-10-03
- Original language: English
- Number of items: 1
- Dimensions: 10.00" h x .88" w x 8.00" l, 1.40 pounds
- Binding: Paperback
- 372 pages
About the Author
Professor Yi Wang is the Faculty Distinguished Professor of Radiology, Professor of Biomedical Engineering, and co-Director of the MRI facility at Cornell University. He is a Fellow of IEEE (Institute of Electrical and Electronics Engineers), ISMRM (International Society of Magnetic Resonance in Medicine), and AIMBE (American Institute for Medical and Biological Engineering). He has been elected to the Council of Distinguished Investigators of the Academy of Radiology Research. He has served as a scientific reviewer of grant applications for many agencies, including the National Institutes of Health (NIH), European Research Council, Research Grants Council of Hong Kong, Swiss National Science Foundation, and the Wellcome Trust of the United Kingdom. As a Principal Investigator, Professor Wang has been awarded many NIH grants for MRI-related research and education and has published more than 160 peer-reviewed journal papers. Professor Wang’s research interest has been in developing MRI technology for clinical applications using methodologies and tools from mathematics, physics, electronic engineering, computer science, and biology. He has developed navigator motion compensation for cardiac MRI, which has become widely adopted in scientific research and clinical practice for cardiac and other MRI. He has pioneered time resolved contrast enhanced MRA, which has become a major field of scientific and clinical cardiovascular MRI activities. He has pioneered multiple station stepping table platform and bolus chase acquisition; the multi-coil array for multi-station as depicted in Professor Wang’s patent has become Siemens’ flagship “Tim - Total image matrix” product. Recently, his group has introduced the quantitative susceptibility mapping (QSM) technique by inverting the magnetic field estimated from MRI signal. QSM is promising for investigating tissue magnetic biomarkers, including deoxyhemoglobin and hemoglobin degradation, ferritin, calcification, myelin, and contrast agents, and has potential applications for a wide range of inflammatory, ischemic and neurodegenerative diseases. Professor Wang is currently working on research projects related to QSM and Bayesian approaches to MRI and applications in the brain, heart, liver and prostate.
Most helpful customer reviews
0 of 0 people found the following review helpful.
An excellent book for notice and veteran alike
By RocRock
In teaching of MRI to students (undergraduate seniors or graduate students), due to the status of current MRI technique (both an important clinical and life science tool and also an active research area that is still drawing many basic scientists into the field), the instructor faces almost insurmountable challenges in a classroom crowded by 10 physics or engineering students and another 10 of biology major: how to make the complicated concepts that are best described by mathematical equations to students with minimal calculus (let alone Maxell equations in electromagnetism), or to explain how synapsis or hemodynamics in brain works to non-biological students. The author of the book must have thought about the challenge for a long time, and has attempted to organize the book so that it can be useful for both crowds with quite different background and expectations in their MRI learning endeavor. The author should be congratulated for coming with organization and content of the book, that is unique in containing not only basic concepts but also actual applications in real MRI design; not only explanations but also intrinsic principles behind. The large amount of the book is dedicated to the biophysical effects of MRI which is beyond most of other MRI textbooks have achieved, and “behind scene stories” as appendix in most chapters provides very interesting history or insight of important concepts or events.
Whether the book is successful in educating effectively most students of drastically different backgrounds still needs to be seen, but the book certainly blows some fresh breath into crowded MRI textbook field, and it is fun to read even for veteran practitioners of this still exciting (after 50+ years) field.
0 of 0 people found the following review helpful.
Indispensable textbook and reference for MR practitioners
By Kofi Deh
With an emphasis on rigor, this book shows the physical origin of the MR signal, describes the k-space formalism for analyzing MR acquisitions and several pulse sequences for obtaining the desired image contrast. In addition to descriptions of traditional MRI, an entire chapter is dedicated to the emerging technology of measurement of tissue magnetism, also known as quantitative susceptibility mapping (QSM), which is being rapidly adopted for quantification of magnetic sources in the body such as iron, blood products and calcification. Another chapter also treats MR imaging of tissue motion in-depth, with descriptions of the state-of-art in diffusion and perfusion MRI. Several clinical applications including imaging of tumors, heart and neurological diseases are provided. An important chapter on MR scanning in the clinic, with an emphasis on safety and legal issues, is also provided. Several problems are provided at the end of each section to help students assess their understanding of the material. This book is an indispensable textbook for a course in MRI or medical imaging. Physicists, especially, will love the rigor with which results are derived. MR researchers and clinicians interested in an in-depth understanding and in keeping up to date with current developments in the field will find this book a great reference.
0 of 0 people found the following review helpful.
The large amount of graphic illustrations and clinical study results make many abstract concepts easy to understand
By Ray Lee
This book elegantly puts MRI and its biomedical applications on a solid physics footing. It is an valuable reference book for quantitatively understand the imaging mechanism.as well as applying the physical principles into basic and clinical researches. What is remarkable about this book, in my opinion, is that it offers many unique, novel, and insightful explanations in some quite traditional topics, e.g. weighted phase graph and quantitative susceptibility mapping, etc., so that its breadth and depth invite both novices and experts. The large amount of graphic illustrations and clinical study results make many abstract concepts easy to understand, even though one of the goals of the book seems to emphasize on the completeness of the symbolic formation of MR imaging principles.
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